Never just wing a job interview. Prepare by developing, reciting, and rehearsing good answers to all of the most common questions. The most feared traditional question is “What is your biggest weakness?” This must be handled delicately and, above all, not honestly. Your prospective employer does not need to know about your alcoholism, difficulty working on teams, or emotional intimacy problems with significant others.
The main character in Zach Cranor’s Last Place Comics appears to make the mistake of being forthright about his weakness: he takes double damage from fire-based attacks. But he has only deceived the interviewer, which is not necessarily a better choice.